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研究成果

NBbiolab is a specialized company focused on the early discovery of single domain antibodies,

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研究成果

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2025
Scientific Reports

Nanobody-based indirect competitive ELISA for the detection of aflatoxin M1 in dairy products

Li Yi, Haiyuan Liu, Yingda Liu, Aiyisi, Jing He, Liang Ming & Jirimutu
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2024
J Nucl Med

CD38-specific immunoPET imaging for multiple myeloma diagnosis and therapeutic monitoring: preclinical and first-in-human studies

Wenpeng Huang , Tianyao Wang , Yongkang Qiu , Chenzhen Li , Bo Chen , Lele Song , Qi Yang , Xinyao Sun , Bing Jia , Lei Kang
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2024
Current Research in Microbial Sciences

Alpaca-derived nanobody targeting the hydrophobic pocket of the HIV-1 gp41 NHR broadly neutralizes HIV-1 by blocking six-helix bundle formation

Lujia Sun, Bo Chen, Xianbo Liu, Yun Zhu, Guangxu Zhang, Xiaoxing Liang, Lixiao Xing, Wei Xu, Shibo Jiang, Xinling Wang
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2024
J Nucl Med

68Ga-NC-BCH Whole-Body PET Imaging Rapidly Targets Claudin18.2 in Lesions in Gastrointestinal Cancer Patients

Changsong Qi , Rui Guo , Yan Chen, Chenzhen Li , Chang Liu, Miao Zhang, Cheng Zhang , Xiaotian Zhang , Xingguo Hou, Bo Chen, Bing Jia, Zhi Yang, Lin Shen, Hua Zhu
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2023
Nature Communications

Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1

Chen Wang, Leiye Yu, Jiying Zhang, Yanxia Zhou, Bo Sun, Qingjie Xiao, Minhua Zhang, Huayi Liu, Jinhong Li, Jialu Li, Yunzi Luo, Jie Xu, Zhong Lian, Jingwen Lin, Xiang Wang, Peng Zhang, Li Guo, Ruobing Ren & Dong Deng
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2022
Nature Communications

Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.

Mingxi Li, Yifei Ren, Zhen Qin Aw, Bo Chen, Ziqing Yang, Yuqing Lei, Lin Cheng, Qingtai Liang, Junxian Hong, Yiling Yang, Jing Chen, Yi Hao Wong, Jing Wei, Sisi Shan, Senyan Zhang, Jiwan Ge, Ruoke Wang, Jay Zengjun Dong, Yuxing Chen, Xuanling Shi, Qi …
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2022
Molecular Pharmaceutics

99mTc-CD3813: A Nanobody-Based Single Photon Emission Computed Tomography Radiotracer with Clinical Potential for Myeloma Imaging and Evaluation of CD38 Expression

Linqing Shi, Bo Chen, Tianyu Liu, Liqiang Li , Biao Hu, Chenzhen Li, Bing Jia, Fan Wang
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2022
EJNMMI

Pilot study of a novel nanobody 68 Ga-NODAGA-SNA006 for instant PET imaging of CD8+ T cells

Yan Wang, Chao Wang, Minzhou Huang, Songbing Qin, Jun Zhao, Shibiao Sang, Meng Zheng, Yicong Bian, Chenrong Huang, Hua Zhang, Lingchuan Guo, Jiwei Jiang, Chun Xu, Na Dai, Yushuang Zheng, Jiajun Han, Min Yang, Tao Xu, Liyan Miao
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2022
Frontiers in Immunology

A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding

Jing Yang, Sheng Lin, Honglu Sun, Zimin Chen, Fanli Yang, Xi Lin, Liyan Guo, Lingling Wang, Ao Wen, Xindan Zhang, Yushan Dai, Bin He, Yu Cao, Haohao Dong, Xianbo Liu, Bo Chen, Jian Li, Qi Zhao, Guangwen Lu
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2020
RSC Advances

Development of a nanobody tagged with streptavidin-binding peptide and its application in a Luminex fluoroimmunoassay for alpha fetal protein in serum

Qi Chen, Danyang Sun, Hua Pei, Benchao Su, Kunlu Bao, Hongmei Cao, Chenghui Zhang, Bruce D Hammock, Xing Liu

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